Successful management approach for Wilms tumor metastatic to the skull treated with regimen I chemotherapy in 10th week: A case report

Wilms tumor is the most common pediatric renal malignancy, while skull metastasis is rare, occurring in fewer than 2% of cases. We report a five-year-old girl with stage II anaplastic nephroblastoma who developed skull metastasis two months after radical nephrectomy. She received 24 weeks of regimen I chemotherapy. The skull mass regressed by week six and completely resolved by week ten, with full closure of the exposed area by week eighteen. Adverse effects included alopecia, nausea, anemia, and leukopenia. Post-treatment imaging showed no residual skull lesion. Regimen I demonstrated an effective therapeutic response in this rare presentation.