Macrophages in psoriasis: a bibliometric analysis of research trends, knowledge gaps, and future directions (2015–2024)

Objective: To systematically analyze the research landscape, knowledge structure, and evolution hotspots in macrophages and psoriasis research over the past decade through bibliometric analysis, providing guidance for mechanistic investigation and therapeutic strategies. Methods: Literature published between January 2015 and December 2024 was retrieved from the Web of Science database and Scopus. The softwares CiteSpace, VOSviewer, Scimago Graphica, and Excel were employed for bibliometric analysis, including co-occurrence networks, clustering analysis, and keyword evolution analysis. Results: played pivotal roles in knowledge dissemination. Research hotspots evolved from fundamental inflammatory mechanisms to targeted biologic therapies, highlighting a growing emphasis on precision medicine and the immunopathogenesis of psoriasis. Conclusion: Macrophage and psoriasis-related research represents a rapidly evolving interdisciplinary field transitioning from isolated pathological studies to comprehensive research integrating advanced technologies with clinical applications. While substantial progress has been achieved in exploring macrophage roles in psoriasis pathogenesis, significant gaps remain between laboratory discoveries and clinical translation. Future research should prioritize international collaboration, application studies, and precision therapeutic strategies targeting macrophage-mediated pathways.