Case Report: Diagnosis of leptospirosis presenting as aseptic meningitis using metagenomics CAPture sequencing

Background: infection manifesting as aseptic meningitis in China. Case presentation: . Following a course of antibiotics and methylprednisolone therapy, the patient fully recovered. Conclusion: This case underscores the importance of considering leptospirosis in differential diagnoses for aseptic meningitis, especially in individuals with occupational risks related to water or animal exposure. MetaCAP's extensive coverage, sensitivity, and early pathogen detection capabilities can significantly enhance patient outcomes.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-04-15
DOI
https://doi.org/10.3389/fmed.2026.1734396
Primary Topic
Leptospirosis research and findings
Type
article
Field-Weighted Citation Impact
0.00
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article

Case Report: Diagnosis of leptospirosis presenting as aseptic meningitis using metagenomics CAPture sequencing

何丹, C Y Zhang, Y. Fan, Wenhua Li et al.
Frontiers in Medicine
Leptospirosis research and findings
article

Case Report: Diagnosis of leptospirosis presenting as aseptic meningitis using metagenomics CAPture sequencing

何丹, C Y Zhang, Y. Fan, Wenhua Li, Ying Bi, Shuang Wu, Mengling Wu, Yan Xu
article en

Abstract

Background: infection manifesting as aseptic meningitis in China. Case presentation: . Following a course of antibiotics and methylprednisolone therapy, the patient fully recovered. Conclusion: This case underscores the importance of considering leptospirosis in differential diagnoses for aseptic meningitis, especially in individuals with occupational risks related to water or animal exposure. MetaCAP's extensive coverage, sensitivity, and early pathogen detection capabilities can significantly enhance patient outcomes.

Frontiers in MedicineVol. 13
Wuhan University (CN), Wuhan City Chinese Medicine Hospital (CN), Wuhan No.1 Hospital (CN), Zhongnan Hospital of Wuhan University (CN)
Good health and well-being
Openalex Percentile: Top 24%
Leptospirosis research and findings
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Case Report: Diagnosis of leptospirosis presenting as aseptic meningitis using metagenomics CAPture sequencing — 何丹, C Y Zhang, et al. · Frontiers in Medicine (2026) | TGRS Research Map | TGRS