Formulation and Comparative Evaluation of Sustained Release Matrix Tablet with a Marketed Diclofenac Gel

In this study, we used natural polymers (Ocimum Sanctum Linn and Acacia powders) in various formulations to create sustained release matrix tablets of Nimesulide. (F1 to F4). The pre-compression characteristics of bulk density, tapped density, angle of repose, compressibility (Carr's index), and Hausner's ratio were assessed for the tablets made using the wet granulation process. Additionally, post-compression parameters such as weight fluctuation, drug content, hardness, thickness, and friability tests were evaluated for the produced tablets. Different formulations demonstrated sustained release of Nimesulide over a ten-hour period, according to in vitro release experiments. Following that, we conducted a permeation investigation of commercially available Diclofenac gel using Franz diffusion cells, and we came to the conclusion that tablet formulations continue to be the best option for producing steady, systemic, and long-lasting therapeutic effects in arthritis. For all-encompassing, long-term arthritis management, tablets continue to be the preferred and more effective primary dosage form. This indicates the potential application of natural polymers in sustained drug delivery systems, improved patient compliance, reduced dose frequency, and repeatable drug release characteristics. Keywords: Nimesulide, Ocimum Sanctum Linn powder, Acacia powder, sustained release matrix tablets, Diclofenac gel