Leveraging Diverse Bi-Triazine Cross-linkers for Modulating Conformation and Biological Activity of Cyclic and Dimeric Peptides
with high tumor contrast (∼5 %ID/mL) but also provides a generalizable framework for precision peptide engineering.
Authors
- Quan Zuo (ORCID: https://orcid.org/0000-0002-4451-3380)
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Ximiao Yang
- H Huang
- Qian Lü (ORCID: https://orcid.org/0000-0001-7271-5804)
- Quanshu He (ORCID: https://orcid.org/0009-0000-1685-1609)
- Zirui Zhang (ORCID: https://orcid.org/0000-0002-3011-3247)
- Jieting Shen (ORCID: https://orcid.org/0000-0002-4331-8399)
- Qichen Hu (ORCID: https://orcid.org/0009-0007-1924-1807)
- Rui Wang (ORCID: https://orcid.org/0000-0002-4719-9921)
- Jiang Wu
- Z Huang
- Jie Yan
- Junlong Lu
- Hao Tian
Institutions
- Shenyang Pharmaceutical University (CN)
- Target (United States) (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00693
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chinese Academy of Medical Sciences
- Peking Union Medical College
- Beijing Municipal Natural Science Foundation
- Beijing Nova Program