Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats

-agonist side effects were less intense and of shorter duration. These data provide proof-of-concept support for the potential use of DEX-KET in producing deeper sedation in METH-induced agitation.

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Publication Details

Journal
Journal of Pharmacy & Pharmaceutical Sciences
Published
2026-04-15
DOI
https://doi.org/10.3389/jpps.2026.16294
Primary Topic
Veterinary Pharmacology and Anesthesia
Type
article
Field-Weighted Citation Impact
0.00
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article

Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats

Michael D. Hambuchen, K. Bailey, Todd H. Davies, Jyostna Yalakala et al.
Journal of Pharmacy & Pharmaceutical Sciences
Veterinary Pharmacology and Anesthesia
article

Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats

Michael D. Hambuchen, K. Bailey, Todd H. Davies, Jyostna Yalakala, Surya Karuturi, Madison B. Skeen, Chelsey McPhillen, Madhuri Budamkayala
article en

Abstract

-agonist side effects were less intense and of shorter duration. These data provide proof-of-concept support for the potential use of DEX-KET in producing deeper sedation in METH-induced agitation.

Journal of Pharmacy & Pharmaceutical SciencesVol. 29
Marshall Medical Center (US), Marshall Health (US), Marshall University (US)
Good health and well-being
Openalex Percentile: Top 23%
Veterinary Pharmacology and Anesthesia
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