Gut Microbiota Mediates HFPO–DA-Induced Hepatotoxicity via Arginine Reprogramming in Lean NAFLD Mice
and the promoted arginine and energy metabolism further evidenced the critical role of gut microbiota in lean NAFLD. This study identified a novel gut-liver axis mediated by arginine and bile acids, elucidating how gut microbiota confer HFPO-DA hepatotoxicity via arginine metabolic reprogramming in lean NAFLD.
Authors
- J ZHANG
- Feng Zhao (ORCID: https://orcid.org/0000-0002-1525-042X)
- Rui Ding (ORCID: https://orcid.org/0000-0002-0426-878X)
- Rui Guo (ORCID: https://orcid.org/0009-0009-1640-4644)
- Nana Zhan (ORCID: https://orcid.org/0009-0001-1193-6387)
- Xiaochun Tian
- Lisong Chen (ORCID: https://orcid.org/0009-0000-9282-440X)
Institutions
- Fujian Normal University (CN)
- Fujian Medical University (CN)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Institute of Urban Environment (CN)
- Shimadzu (China) (CN)
- Nano Carbon (Poland) (PL)
Publication Details
- Journal
- Environmental Science & Technology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.est.6c02839
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province