A silver lining … in the ureter: Keratinizing squamous metaplasia with a metallic twist
Silver or metallic-appearing urinary tract mucosa is exceedingly rare and typically attributed to exogenous metal exposure. We report a case of a diffusely silver-appearing ureter in a 65-year-old man with a history of squamous cell carcinoma of the bladder and chronic intermittent self-catheterization. Imaging revealed no metallic or calcified material, and histopathology demonstrated extensive squamous metaplasia with marked hyperkeratosis. We hypothesize that dense keratin accumulation produced a pseudo-metallic appearance without true metal deposition. This case highlights a novel gross ureteral appearance likely related to chronic inflammation-induced keratinizing changes, expanding the differential for "silver" urothelial mucosa.
Authors
- Abhinav Khanna
- John C. Cheville (ORCID: https://orcid.org/0000-0002-8202-6268)
- Tae-Hee Kim (ORCID: https://orcid.org/0009-0006-8357-9522)
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Urology Case Reports
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.eucr.2026.103449
- Primary Topic
- Urologic and reproductive health conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00