A silver lining … in the ureter: Keratinizing squamous metaplasia with a metallic twist

Silver or metallic-appearing urinary tract mucosa is exceedingly rare and typically attributed to exogenous metal exposure. We report a case of a diffusely silver-appearing ureter in a 65-year-old man with a history of squamous cell carcinoma of the bladder and chronic intermittent self-catheterization. Imaging revealed no metallic or calcified material, and histopathology demonstrated extensive squamous metaplasia with marked hyperkeratosis. We hypothesize that dense keratin accumulation produced a pseudo-metallic appearance without true metal deposition. This case highlights a novel gross ureteral appearance likely related to chronic inflammation-induced keratinizing changes, expanding the differential for "silver" urothelial mucosa.

Authors

Institutions

Publication Details

Journal
Urology Case Reports
Published
2026-04-15
DOI
https://doi.org/10.1016/j.eucr.2026.103449
Primary Topic
Urologic and reproductive health conditions
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A silver lining … in the ureter: Keratinizing squamous metaplasia with a metallic twist

Abhinav Khanna, John C. Cheville, Tae-Hee Kim
Urology Case Reports
Urologic and reproductive health conditions
article

A silver lining … in the ureter: Keratinizing squamous metaplasia with a metallic twist

Abhinav Khanna, John C. Cheville, Tae-Hee Kim
article en

Abstract

Silver or metallic-appearing urinary tract mucosa is exceedingly rare and typically attributed to exogenous metal exposure. We report a case of a diffusely silver-appearing ureter in a 65-year-old man with a history of squamous cell carcinoma of the bladder and chronic intermittent self-catheterization. Imaging revealed no metallic or calcified material, and histopathology demonstrated extensive squamous metaplasia with marked hyperkeratosis. We hypothesize that dense keratin accumulation produced a pseudo-metallic appearance without true metal deposition. This case highlights a novel gross ureteral appearance likely related to chronic inflammation-induced keratinizing changes, expanding the differential for "silver" urothelial mucosa.

Urology Case ReportsVol. 66
Mayo Clinic (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Zero hunger
Openalex Percentile: Top 28%
Urologic and reproductive health conditions
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.