Serum albumin-fused interleukin-10 prevents neuroinflammation by promoting immunoregulation in the secondary lymphoid organs and limiting immune cell infiltration in the spinal cord
T cells into the spinal cord. Repeated SA-IL-10 administration was well tolerated, as treated EAE mice gained significantly more body weight over the course of treatment compared to PBS- and WT IL-10-treated controls, and exhibited plasma biochemistry parameters comparable to control animals at study endpoint. Together, these findings demonstrate that increasing IL-10 exposure in the SLOs suppresses neuroinflammation by promoting immunoregulation. One Sentence Summary: 17 cells and pro-inflammatory myeloid cells in the secondary lymphoid organs and spinal cord, while expanding immunoregulatory cells in the secondary lymphoid organs.
Authors
- Lisa R. Volpatti (ORCID: https://orcid.org/0000-0001-6197-0703)
- Jeffrey A. Hubbell (ORCID: https://orcid.org/0000-0003-0276-5456)
- Kirsten C. Refvik (ORCID: https://orcid.org/0009-0006-0585-5827)
- Abigail L. Lauterbach (ORCID: https://orcid.org/0000-0001-8271-8777)
- Ani Solanki (ORCID: https://orcid.org/0000-0002-7190-7852)
- Julia Luehr
- Ivan Vuong (ORCID: https://orcid.org/0000-0002-3946-4772)
- Joseph W. Reda (ORCID: https://orcid.org/0000-0002-9413-5111)
- Erica Budina (ORCID: https://orcid.org/0000-0001-8510-0497)
- Taryn N. Beckman (ORCID: https://orcid.org/0000-0002-4634-3856)
- Brendan T. Berg
- Sofia N. Reda
- Jun Ishihara
- Mindy Nguyen
- Colleen R. Foley
- Hye-Rin Chun
- Kevin Hultgren
- Suzana Gomes
Institutions
- Northwestern University (US)
- University of Chicago (US)
- NYU Langone Health (US)
- Imperial College London (GB)
- New York University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-14
- DOI
- https://doi.org/10.64898/2026.04.10.717764
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00