Outwitting the Hypoxic Fortress: Self-Assembled Glucose-Powered Mitochondria-Targeting Ru Nanoassemblies for Triad Chemo-Sonodynamic Immunotherapy
and acts as a Fenton-like catalyst for chemodynamic therapy. ROS also promote iron release from Hb, establishing a self-sustaining feedback loop that intensifies oxidative stress. This ROS storm disrupts redox homeostasis and induces immunogenic cell death via ferroptosis, reprogramming the immunosuppressive TME. This work overcomes SDT limitations through a self-reinforcing multimodal therapeutic cycle for precision cancer treatment.
Authors
- Qing‐Hua Shen (ORCID: https://orcid.org/0000-0001-8359-9626)
- Long‐Bo Yu
- Ying-Ying Han
- Peng Wang
- Zhi-Yuan Li
- Xiang-Jie Jiang
Institutions
- Sun Yat-sen University (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00767
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province