An <i>hcp3-vgrG3</i> intergenic region participates in EHEC T6SS expression in addition to the bidirectional promoter and H-NS
was not enough for full activation, and additional activation was required to produce some, but not all, proteins, causing a loss of bacterial fitness. These findings bring us closer to a full understanding of the mechanisms that control its expression. We predict novel regulation sites that will be necessary to fully understand the activation mechanisms and, thus, the function of T6SS in EHEC and perhaps other bacteria.
Authors
- Jaime Vazquez-Lopez (ORCID: https://orcid.org/0000-0003-3575-5596)
- Fernando Navarro‐García (ORCID: https://orcid.org/0000-0002-9031-3232)
- Jazmín Huerta-Cantillo
- Luis A. Constantino‐Jonapa (ORCID: https://orcid.org/0000-0003-0773-2581)
- Landy Zambrano-Arguello
- Juan M. Jimenez-Antaño
Institutions
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1128/spectrum.03548-25
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional