Relaxation Suppressed Exchange Tuning MRI Integrated with Manganese-Based Nanozyme Probes for Ferroptosis Induction and GPX4 Monitoring
provides a sensitive and specific indicator for visualizing glutathione peroxidase 4 (GPX4) expression, thereby enabling cross-modal monitoring of ferroptosis. Meanwhile, we revealed that the ReSET strategy enables sensitive detection of small lesions in liver micrometastasis models. Overall, we establish a ReSET MRI-guided strategy using a manganese-based nanoplatform, which represents a promising ferroptosis-related theranostic approach for TNBC.
Authors
- Jiali Deng (ORCID: https://orcid.org/0000-0002-6931-533X)
- Jingyi Wang (ORCID: https://orcid.org/0000-0002-8583-237X)
- Xiance Zhao
- Xin Ding (ORCID: https://orcid.org/0000-0001-9267-2899)
- Zhu Mei (ORCID: https://orcid.org/0000-0002-7910-1247)
- Zhongling Wang (ORCID: https://orcid.org/0000-0002-5477-1287)
- Hongwei Lu (ORCID: https://orcid.org/0000-0002-2886-7410)
- Yi Zhu
- Jingyan Fang
- An Chen
Institutions
- Philips (Finland) (FI)
- University of Shanghai for Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Shantou University (CN)
- Shanghai First People's Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Pancreas Centre (Canada) (CA)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acsabm.6c00454
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Key Laboratory of Molecular Imaging