Clearance of Senescent Cells by <scp> BCL <sub>XL</sub> </scp> ‐ <scp>PROTAC</scp> : A Novel Approach to Treat <scp>COPD</scp> ?
-PROTAC is a potent and selective senolytic agent that may promote lung cell rejuvenation, supporting its potential as a novel therapeutic strategy for age-related diseases, including COPD.
Authors
- Raphaël Lemaire
- Lina Odqvist (ORCID: https://orcid.org/0000-0001-6002-0968)
- Patrizia Viola (ORCID: https://orcid.org/0000-0002-2869-3908)
- Neetu Razdan
- Justine Devulder (ORCID: https://orcid.org/0000-0001-9958-316X)
- Peter J. Barnes (ORCID: https://orcid.org/0000-0002-5122-4018)
- May Al‐Sahaf (ORCID: https://orcid.org/0000-0002-8973-7302)
- Hiromi Kudo (ORCID: https://orcid.org/0000-0003-4313-7165)
- Ewa Kołosionek
- Anthony Sinadinos
- Louise E. Donnelly
- Peter S. Fenwick
Institutions
- Imperial College Healthcare NHS Trust (GB)
- AstraZeneca (Finland) (FI)
- Imperial College London (GB)
Publication Details
- Journal
- Aging Cell
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1111/acel.70487
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Centre