Identification of Reactive Metabolites of Acetaminophen and Saxagliptin in Human Hepatocytes and Hepatic Organoids
: HHOs system can be used as an in vitro model for screening reactive metabolites, comparable to those obtained with CHHs.
Authors
- Im‐Sook Song (ORCID: https://orcid.org/0000-0002-4564-709X)
- Minyeong Pang (ORCID: https://orcid.org/0000-0003-0831-930X)
- Min Seo Lee (ORCID: https://orcid.org/0000-0003-3448-6208)
- Kwang‐Hyeon Liu (ORCID: https://orcid.org/0000-0002-3285-5594)
- Han‐Jin Park (ORCID: https://orcid.org/0000-0002-0113-4145)
- Hyemin Kim (ORCID: https://orcid.org/0000-0002-3440-8456)
- Min-Koo Choi
Institutions
- Kyungpook National University (KR)
- Korea Institute of Toxicology (KR)
- The Catholic University of Korea Bucheon St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
- Dankook University (KR)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/pharmaceutics18040483
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Institute of Toxicology
- National Research Foundation of Korea