Unexpected Effect of Digestion Products of Infant Formula in Enhancing the Solubilisation of Tolfenamic Acid During Digestion
These results show that a weakly acidic drug can also exhibit digestion-driven solubilisation in a lipid-based formulation in the absence of ion-pairing and highlights the need to better understand drug response to digestion of lipid-based foods and formulations, and their versatility as a formulation option even for poorly water-soluble acidic drugs.
Authors
- Ben J. Boyd (ORCID: https://orcid.org/0000-0001-5434-590X)
- Malinda Salim (ORCID: https://orcid.org/0000-0003-1773-5401)
- Thomas Eason
- Vanessa Zann
Institutions
- University of Copenhagen (DK)
- Quotient Clinical (United Kingdom) (GB)
- Monash University (AU)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/pharmaceutics18040480
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Australian Nuclear Science and Technology Organisation
- Australian Synchrotron