Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma
inhibits hexokinase and lactate dehydrogenase, depleting ATP and biosynthetic intermediates. Furthermore, ZnS@GMs induce immunogenic cell death, which triggers dendritic cell maturation, cytotoxic T cell infiltration, and macrophage repolarization, thereby enhancing the efficacy of anti-PD-1 therapy. In a rabbit orthotopic liver tumor model, intra-arterial infusion of ZnS@GMs confirms potent antitumor effects and effective embolic performance. This work establishes ZnS@GMs as a multifunctional platform to overcome TAE resistance in HCC.
Authors
- Weihao Yang (ORCID: https://orcid.org/0000-0002-4568-4640)
- Xiaoxiao Pan (ORCID: https://orcid.org/0000-0002-2162-9807)
- Zifan Pei (ORCID: https://orcid.org/0009-0001-6166-9678)
- Liang Cheng (ORCID: https://orcid.org/0000-0001-5324-9094)
- Binyan Zhong
- Jiachen Xu
- Zhi Li (ORCID: https://orcid.org/0000-0002-3750-3125)
- Jian Shen
- Caifang Ni
- Bin Yu
- Jie Cao
- Fei Gong
- Nan Jiang
Institutions
- Soochow University (CN)
- Zhejiang Cancer Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.xcrm.2026.102748
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00