<i>Ophiopogon japonicus</i> Polysaccharides Promote Microbial Production Of Chenodeoxycholic Acid To Alleviate Ulcerative Colitis in Mice by Inhibiting the STING1-Related NF-κB Pathway
can significantly repair gut barrier dysfunction and alleviate intestinal inflammation in DSS-induced UC mice. Mechanistically, CDCA treatment strikingly inhibited the STING1-related NF-κB pathway in UC mice probably by binding to STING1, thus strongly suppressing colonic inflammatory status. These results suggest that OJP has potential preventive or therapeutic effects for inflammatory diseases.
Authors
- Xinzhi Li
- Hehua Lei (ORCID: https://orcid.org/0000-0001-5088-376X)
- Yan He (ORCID: https://orcid.org/0000-0003-0307-2651)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Xia Gao (ORCID: https://orcid.org/0009-0001-0480-1468)
- Qingwei Xiang
- Cui Zhang
- Zhiwen Zhang
- Weichuan Lin
- Zeman Zhao
- Gang Chen
- Zheng Cao
Institutions
- Macau University of Science and Technology (MO)
- Hubei University of Medicine (CN)
- National Academy of Governance (MN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Wuhan Institute of Physics and Mathematics (CN)
- Drug Discovery Laboratory (Norway) (NO)
- Resonance Research (United States) (US)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acs.jafc.5c14733
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Science and Technology Program of Hubei Province