Structure matters: commensal Phocaeicola vulgatus lipopolysaccharide induces attenuated microglial activation and preserves neuronal integrity
-treated microglia did not. Overall, our data argue that "LPS-induced neuroinflammation" is not a universal phenomenon, but a chemistry-dependent outcome shaped by specific LPS structures. This study therefore highlights the need to consider LPS structural diversity in neuroinflammation models, particularly in the context of gut-brain communication.
Authors
- Flaviana Di Lorenzo (ORCID: https://orcid.org/0000-0003-4821-0114)
- Valentina Mazziotti (ORCID: https://orcid.org/0000-0002-8746-1082)
- Alba Silipo (ORCID: https://orcid.org/0000-0002-5394-6532)
- Fabrizio Chiodo (ORCID: https://orcid.org/0000-0003-3619-9982)
- Luca De Simone Carone
- Francesca Olmeo
- Antonio Molinaro
Institutions
- Institute of Organic Chemistry (PL)
- CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
- University of Naples Federico II (IT)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3389/fncel.2026.1796397
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- HORIZON EUROPE European Research Council