Designer Podophyllotoxin Derivatives with Significantly Improved Safety by Targeting LAT1 for the Treatment of Esophageal Cancer
could accumulate in tumor cells in a LAT1-dependent manner and exert its antitumor effects by cytoskeleton disruption.
Authors
- 朱萧玲
- Ru Zhang (ORCID: https://orcid.org/0000-0002-1661-5638)
- Shengnan Liu (ORCID: https://orcid.org/0000-0001-9886-068X)
- Xu Gao (ORCID: https://orcid.org/0000-0003-1521-9948)
- Manwei Jia
- Chang Zheng
- Jianbin Han
- Yang Liu
Institutions
- Ministry of Education of the People's Republic of China (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03829
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin University