Clinical utility of fecal Sanger sequencing and PCR alongside gastric biopsy E-test for <i>Helicobacter pylori</i> resistance to clarithromycin and quinolone
susceptibility pattern and can therefore be used to tailor empirical therapy without the need for invasive culture. IMPORTANCE: mutations showed ≥85% agreement with invasive E-test results, enabling age-stratified, resistance-guided eradication therapy without endoscopy or culture.
Authors
- Linjie Peng (ORCID: https://orcid.org/0000-0003-1400-4611)
- Haitao Hu (ORCID: https://orcid.org/0000-0003-0708-6233)
- Juan Xu
- Yan Zhao
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Changzhou No.2 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1128/spectrum.04062-25
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Medical University