Medullary cavity expansion is mediated by distinct cell populations during fetal bone development

BMSCs are redeployed within the callus, indicating reactivation of a developmental osteogenic program. Together, our findings uncover a conserved mechanism that links skeletal remodeling to the establishment of the BM microenvironment required for hematopoiesis.

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Publication Details

Journal
Nature Communications
Published
2026-04-14
DOI
https://doi.org/10.1038/s41467-026-71952-5
Primary Topic
Developmental Biology and Gene Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Medullary cavity expansion is mediated by distinct cell populations during fetal bone development

Yumiko Kitada, Kenta Nakano, Yuki Yoshimura, Yuki Matsushita et al.
Nature Communications
Developmental Biology and Gene Regulation
article

Medullary cavity expansion is mediated by distinct cell populations during fetal bone development

Yumiko Kitada, Kenta Nakano, Yuki Yoshimura, Yuki Matsushita, Chie Kikutake, Mikita Suyama, Mamoru Ito, Yasuhiro Go, Lucie Peduto, Tadashi Okamura, Shinichiro Sawa, Manabu Nakayama, Yuka Morioka, Motohito Goto, Kohei Saeki, Haruhiko Akiyama, Mami Kurumata-Shigeto, Noriko Kurisaki, Eriko Sumiya, Natsuko Nakaima
article en

Abstract

BMSCs are redeployed within the callus, indicating reactivation of a developmental osteogenic program. Together, our findings uncover a conserved mechanism that links skeletal remodeling to the establishment of the BM microenvironment required for hematopoiesis.

Nature Communications
University of Nagasaki (JP), Kyushu University (JP), Okayama University of Science (JP), Institut Pasteur (FR), University of Hyogo (JP), National Institutes of Natural Sciences (JP), Hokkaido University (JP), Central Institute for Experimental Animals (JP), National Center for Global Health and Medicine (JP), National Center of Neurology and Psychiatry (JP), National Institute for Physiological Sciences (JP), Kazusa DNA Research Institute (JP), National Institute of Animal Health (JP), Gifu University (JP), Nagasaki University (JP), Tottori University (JP), Kobe University (JP)
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Openalex Percentile: Top 17%
Developmental Biology and Gene Regulation
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