Medullary cavity expansion is mediated by distinct cell populations during fetal bone development
BMSCs are redeployed within the callus, indicating reactivation of a developmental osteogenic program. Together, our findings uncover a conserved mechanism that links skeletal remodeling to the establishment of the BM microenvironment required for hematopoiesis.
Authors
- Yumiko Kitada
- Kenta Nakano (ORCID: https://orcid.org/0000-0003-2617-1468)
- Yuki Yoshimura (ORCID: https://orcid.org/0000-0001-7092-6683)
- Yuki Matsushita (ORCID: https://orcid.org/0000-0001-9577-3249)
- Chie Kikutake (ORCID: https://orcid.org/0000-0002-9571-641X)
- Mikita Suyama (ORCID: https://orcid.org/0000-0001-9526-3193)
- Mamoru Ito (ORCID: https://orcid.org/0000-0002-5373-8223)
- Yasuhiro Go (ORCID: https://orcid.org/0000-0003-4581-0325)
- Lucie Peduto (ORCID: https://orcid.org/0000-0003-2414-4407)
- Tadashi Okamura (ORCID: https://orcid.org/0000-0001-8457-1561)
- Shinichiro Sawa (ORCID: https://orcid.org/0000-0002-8850-446X)
- Manabu Nakayama (ORCID: https://orcid.org/0009-0001-0488-1664)
- Yuka Morioka
- Motohito Goto (ORCID: https://orcid.org/0000-0001-6288-4583)
- Kohei Saeki
- Haruhiko Akiyama
- Mami Kurumata-Shigeto
- Noriko Kurisaki
- Eriko Sumiya (ORCID: https://orcid.org/0009-0005-7086-3287)
- Natsuko Nakaima
Institutions
- University of Nagasaki (JP)
- Kyushu University (JP)
- Okayama University of Science (JP)
- Institut Pasteur (FR)
- University of Hyogo (JP)
- National Institutes of Natural Sciences (JP)
- Hokkaido University (JP)
- Central Institute for Experimental Animals (JP)
- National Center for Global Health and Medicine (JP)
- National Center of Neurology and Psychiatry (JP)
- National Institute for Physiological Sciences (JP)
- Kazusa DNA Research Institute (JP)
- National Institute of Animal Health (JP)
- Gifu University (JP)
- Nagasaki University (JP)
- Tottori University (JP)
- Kobe University (JP)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1038/s41467-026-71952-5
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00