Utility of Native T1 Mapping for the Evaluation of Myocardial Iron Overload in Patients with Thalassemia Major
: Native T1 mapping is highly sensitive for detecting myocardial iron overload in Thalassemia Major, but the standard 990 ms threshold generates many false-positive results. In our cohort, adopting an ROC-optimized threshold of 895.5 ms markedly improved specificity while preserving excellent sensitivity.
Authors
- Davide Turilli (ORCID: https://orcid.org/0000-0002-2063-994X)
- Leandra Piscopo (ORCID: https://orcid.org/0009-0000-5487-1360)
- Antonio Matteo Amadu
- Salvatore Claudio Fanni (ORCID: https://orcid.org/0000-0002-4003-3320)
- E Solinas
- Alberto Dessì (ORCID: https://orcid.org/0000-0003-0353-1360)
- M Scaglione
- Salvatore Masala
- Alessio Contena
Institutions
- University of Pisa (IT)
- University of Sassari (IT)
Publication Details
- Journal
- Tomography
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/tomography12040058
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00