Possible Role of Diffusion-Weighted Imaging in Prediction of Prostate Cancer Grade Group Upgrading: Insights from Biopsy to Radical Prostatectomy
: Quantitative diffusion parameters-particularly ADC and kurtosis (K)-demonstrated significant predictive value for Grade Group upgrading in patients with biopsy-proven GG1 (AUC: K = 0.846, ADC = 0.762) and GG2 (AUC: ADC = 0.814, K = 0.755, D = 0.810) prostate cancer. These findings suggest that incorporating quantitative DWI parameters into preoperative assessments may improve risk stratification and support clinical decision-making, particularly regarding the selection of patients for active surveillance. Validation in larger, multicenter cohorts is warranted.
Authors
- Marcin Matuszewski (ORCID: https://orcid.org/0000-0002-7799-685X)
- Anna Żurowska (ORCID: https://orcid.org/0000-0003-4107-6821)
- Małgorzata Grzywińska (ORCID: https://orcid.org/0000-0001-6533-5774)
- Katarzyna Skrobisz (ORCID: https://orcid.org/0000-0003-3710-9037)
- Edyta Szurowska (ORCID: https://orcid.org/0000-0002-7042-4381)
- Rafał Pęksa (ORCID: https://orcid.org/0000-0002-4904-7059)
- Damian Panas (ORCID: https://orcid.org/0000-0003-2181-2414)
- M Sowa
Institutions
- InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
- Gdańsk Medical University (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Medicina
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3390/medicina62040750
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00