Therapeutic Potential of Cysteine and Its Derivatives in Dermatology

), GSH, and related compounds. These derivatives regulate melanogenesis by modulating dopaquinone pathways and tyrosinase activity, maintain collagen balance by preserving redox-sensitive enzymatic processes, and enhance wound healing through antioxidant and anti-inflammatory mechanisms. Importantly, chemical modifications such as acetylation, amidation, and esterification improve pharmacokinetic properties, enabling more effective intracellular delivery. Furthermore, different derivatives exhibit distinct advantages depending on biological context, highlighting the importance of compound selection. Overall, cysteine derivatives emerge as promising therapeutic candidates for dermatological applications, particularly in pigmentation disorders and impaired wound healing. Future studies should focus on in vivo validation and clinical translation.

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Publication Details

Journal
Molecules
Published
2026-04-13
DOI
https://doi.org/10.3390/molecules31081277
Primary Topic
melanin and skin pigmentation
Type
article
Field-Weighted Citation Impact
0.00

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article

Therapeutic Potential of Cysteine and Its Derivatives in Dermatology

Yong Chool Boo, W Lee, Joon Yong Choi
Molecules
melanin and skin pigmentation
article

Therapeutic Potential of Cysteine and Its Derivatives in Dermatology

Yong Chool Boo, W Lee, Joon Yong Choi
article en

Abstract

), GSH, and related compounds. These derivatives regulate melanogenesis by modulating dopaquinone pathways and tyrosinase activity, maintain collagen balance by preserving redox-sensitive enzymatic processes, and enhance wound healing through antioxidant and anti-inflammatory mechanisms. Importantly, chemical modifications such as acetylation, amidation, and esterification improve pharmacokinetic properties, enabling more effective intracellular delivery. Furthermore, different derivatives exhibit distinct advantages depending on biological context, highlighting the importance of compound selection. Overall, cysteine derivatives emerge as promising therapeutic candidates for dermatological applications, particularly in pigmentation disorders and impaired wound healing. Future studies should focus on in vivo validation and clinical translation.

MoleculesVol. 31(8)
Kyungpook National University Hospital (KR), Kyungpook National University (KR)
Korea Health Industry Development Institute
Openalex Percentile: Top 25%
melanin and skin pigmentation
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