YTHDC1 recognizes METTL16-dependent m <sup>6</sup> A on caRNAs and coordinates cotranscriptional splicing
A-YTHDC1 axis that couples RNA modification with cotranscriptional splicing during mammalian organogenesis, providing molecular insights into how epitranscriptomic regulation governs developmental decisions.
Authors
- Junru Wen
- Shuang Jiang (ORCID: https://orcid.org/0000-0002-1182-0018)
- Q H Yin
- L. Liu
- Zhang Zhong (ORCID: https://orcid.org/0000-0001-7331-1908)
- Zirui Wang
- Chunlin Qian
- Chong Chen (ORCID: https://orcid.org/0000-0002-6787-0495)
- Qi Li (ORCID: https://orcid.org/0000-0001-8776-8730)
- Rui Sheng (ORCID: https://orcid.org/0000-0002-5479-0795)
- Kexin Lei (ORCID: https://orcid.org/0000-0003-1273-8849)
- Q Yuan
- Weimin Lin
- Lanxin Zhang
Institutions
- University of Southern California (US)
- Sichuan University (CN)
- National Clinical Research (US)
- Stomatology Hospital (CN)
- State Key Laboratory of Biotherapy
- Nanjing Medical University (CN)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1073/pnas.2524579123
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province