Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids
receptor expression in excitatory neurons in V247X organoids. These findings demonstrate mutation-specific mechanisms of vulnerability in Rett syndrome and suggest targeted strategies for their treatment.
Authors
- Devorah Kranz (ORCID: https://orcid.org/0000-0002-8821-8885)
- Yuma Osako (ORCID: https://orcid.org/0000-0002-7214-4076)
- C N Nelson
- Michela Fagiolini (ORCID: https://orcid.org/0000-0003-2807-803X)
- Tatsuya Osaki (ORCID: https://orcid.org/0000-0001-7174-0629)
- April R. Levin (ORCID: https://orcid.org/0000-0003-4192-4720)
- M. Sur
- Chloé Delépine (ORCID: https://orcid.org/0000-0002-1856-9583)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- International Christian University (JP)
- Whitehead Institute for Biomedical Research (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1038/s41467-026-71458-0
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Mental Health