Bifidobacterium animalis subsp. lactis BL-16 fermented Astragali Radix (W16) promotes the bone growth of juvenile rats via modulation of IGF-1 and gut microbiota
Introduction: , has growth-promoting potential, and fermentation may enhance its bioactivity. Methods: ) expression, IGF-1 levels, glucose/insulin concentrations, and gut microbiota were analyzed. Results: . Discussion: Postbiotic W16 promotes bone growth via regulating growth-related genes, IGF-1 signaling, and gut microbiota. Safer than hGH (no insulin resistance), W16 is a promising functional food candidate for improving short stature in children.
Authors
- Tianjiao Cong
- Feng Cai
- Yanan Yang
- Jiale Cheng
- Yunfeng Duan
- Ying Cao
- Jiacheng Zhang
- Qinghang Zhang
- Ziyi Liu
- Lei Cui
- Chongming Wu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Joint Research Center (ES)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3389/fmicb.2026.1753788
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00