Skin <i>Staphylococcus</i> species differentially modulate keratinocyte cytokine secretion in response to UVB

following UVB exposure. These findings suggest that the resident skin microbiota may contribute to our inflammatory response to sunlight.IMPORTANCEThis study reveals that the skin microbiome may play a role in shaping inflammatory responses to UVB exposure. It provides evidence of organisms capable of both amplifying and mitigating inflammatory responses to UVB, highlighting the importance of microbial composition in photoprotection. These findings suggest individual responses to sunlight may be influenced not only by skin type but also by specific microbes present on the skin.