Cellular Microenvironment Triggered Ferroptosis and Photodynamic Therapy for Selective Senescent Cell Clearance
redox cycle and activate the ferroptosis related process. Under the synergistic photodynamic and ferroptosis effects, the clearance efficiency of senescent cells reached 98%. More importantly, leveraging the senescent cell microenvironment, Fe@N-GQDs showed minimal impact on healthy cells without targeting modifications, significantly improving therapeutic safety.
Authors
- Qiqiang Zhang (ORCID: https://orcid.org/0009-0003-0685-3864)
- Hui Dong (ORCID: https://orcid.org/0000-0002-6444-1134)
- Liangfeng Chen (ORCID: https://orcid.org/0000-0001-5946-1707)
- Yongqiang Li
- Xuelian Wang
- Jia Qi
- Hang Wang
- Siwei Yang (ORCID: https://orcid.org/0000-0002-5227-8210)
- Yuli Kang
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- Shanghai Institute of Microsystem and Information Technology (CN)
- Huashan Hospital (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- ACS Applied Materials & Interfaces
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acsami.6c03395
- Primary Topic
- Carbon and Quantum Dots Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences