Deciphering high density lipoprotein (HDL) structure-function: Detailed analysis of HDL subfractions reveals molecular differences leading to atherosclerosis risk
addressing that particle composition alone cannot fully distinguish HDL dysfunction. Multimodal analysis integrating structural and biochemical data was able to separate risk groups and revealed correlations between structural parameters and cardiovascular risk status. Our findings support the importance of analyzing HDL subfractions to uncover molecular drivers of disease risk and suggest candidate biomarkers for atherosclerosis upon validation in larger cohorts.
Authors
- Felix Roosen‐Runge (ORCID: https://orcid.org/0000-0001-5106-4360)
- Yubexi Correa
- Jan Skov Pedersen (ORCID: https://orcid.org/0000-0002-7768-0206)
- Martin Jansen (ORCID: https://orcid.org/0000-0002-2631-4601)
- Marité Cárdenas
- David Gil-Cartón
- Clement Blanchet
- Birgit Felderer
Institutions
- Ikerbasque (ES)
- Malmö University (SE)
- Lund University (SE)
- Aarhus University (DK)
- University Medical Center Freiburg (DE)
- Fundación Biofísica Bizkaia (ES)
- European Molecular Biology Laboratory (DE)
Publication Details
- Journal
- International Journal of Biological Macromolecules
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1016/j.ijbiomac.2026.152016
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Interreg South Baltic
- Euskal Herriko Unibertsitatea
- Ikerbasque, Basque Foundation for Science
- Vetenskapsrådet