Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy
ABSTRACT Despite decades of intense research, cancer remains a major global health challenge, with a clear need for new and more efficient therapies. Among emerging approaches, high atomic number (Z) nanomaterials capable of modulating the interaction between radiation and matter have attracted growing interest as radiotherapy enhancers. In this work, ultra‐small Platinum‐based nanoparticles with a metallic core diameter of 2–3 nm were synthesized from H 2 PtCl 6 using polyvinylpyrrolidone as stabilizer. This nanomaterial exhibits low acute toxicity, catalase‐like activity and enhances DNA damage under pre‐clinical X‐ray irradiation, increasing the antitumoral effect of X‐ray alone. In vitro and in vivo studies, including intratumoral and intravenous administration, demonstrate improved tumor control and prolonged survival without detectable systemic toxicity under the tested conditions, establishing ultra‐small Pt‐nanoparticles as efficient materials for radiotherapy enhancement.
Authors
- Eduardo J. Caleiras (ORCID: https://orcid.org/0000-0001-8768-3630)
- José I. García-Peiro (ORCID: https://orcid.org/0000-0003-4874-6672)
- Miguel Encinas‐Giménez (ORCID: https://orcid.org/0000-0003-0365-351X)
- Antonio De la Vieja (ORCID: https://orcid.org/0000-0002-1187-1907)
- Pilar Martín‐Duque (ORCID: https://orcid.org/0000-0003-2890-7846)
- Felipe Hornos (ORCID: https://orcid.org/0000-0002-9360-4086)
- J Santamaria
- Laura Notario (ORCID: https://orcid.org/0000-0001-8940-1916)
- Jose L. Hueso
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Universidad de Zaragoza (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Instituto de Nanociencia y Materiales de Aragón (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
- Unidad Funcional de Investigación de Enfermedades Crónicas (ES)
- CIBBIM-Nanomedicine (ES)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1002/adfm.202600051
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Ministerio de Economía y Competitividad
- Ministerio de Ciencia e Innovación
- Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
- Universidad de Zaragoza
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación