Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment
: 2-DG: 2-deoxy-D-glucose; BafA1: bafilomycin A1; CHX: cycloheximide; CTB: cytotrophoblasts; D-gal: D-galactose; EVT: extravillous trophoblasts; HDAC: histone deacetylase; H2O2: hydrogen peroxide; IL33: Interleukin 33; LPS: lipopolysaccharide; SA-GLB1/β-gal: senescence-associated galactosidase beta 1; SASP: senescence-associated secretory phenotype; SNAP29: synaptosome associated protein 29; STB: syncytiotrophoblasts; UMAP: uniform manifold approximation and projection; URPL: unexplained recurrent pregnancy loss; VP: etoposide.
Authors
- Wenting Hu (ORCID: https://orcid.org/0000-0003-4639-9056)
- Yan‐Ran Sheng
- Xiao‐Yong Zhu (ORCID: https://orcid.org/0000-0002-2512-9703)
- Ming‐Qing Li (ORCID: https://orcid.org/0000-0002-9276-0722)
- Yukai Liu (ORCID: https://orcid.org/0000-0003-2384-9173)
- Jia-Jing Lu
- Feng Xie
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1080/15548627.2026.2659946
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China