When Methotrexate Is Not Enough: Hysteroscopic Management of an Angular Pregnancy With Discordant Beta-Human Chorionic Gonadotropin (b-hCG) and Ultrasound Findings

An angular pregnancy is a rare form of ectopic implantation. We report a 30-year-old primigravida presenting with an abnormal beta-human chorionic gonadotropin (b-hCG) trend. At presentation, her b-hCG was 1,950 mIU/mL. Ultrasound showed an angular gestational sac with increased vascularization and deep myometrial extension. Methotrexate was administered, achieving biochemical response but with persistent suspicious ultrasound findings, suggesting ongoing trophoblastic activity. Due to this discordance, hysteroscopic management was performed. The gestational tissue was exposed and removed using a bipolar mini-resectoscope under direct visualization. The patient was discharged the same day. Hysteroscopy may represent a safe and effective option in selected cases with discordant biochemical and imaging findings.

Authors

Publication Details

Journal
Cureus
Published
2026-04-14
DOI
https://doi.org/10.7759/cureus.107054
Primary Topic
Ectopic Pregnancy Diagnosis and Management
Type
article
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article

When Methotrexate Is Not Enough: Hysteroscopic Management of an Angular Pregnancy With Discordant Beta-Human Chorionic Gonadotropin (b-hCG) and Ultrasound Findings

F Toscano, Roberta Gallo, Giuseppe Laurelli, Raffaella Del Papato et al.
Cureus
Ectopic Pregnancy Diagnosis and Management
article

When Methotrexate Is Not Enough: Hysteroscopic Management of an Angular Pregnancy With Discordant Beta-Human Chorionic Gonadotropin (b-hCG) and Ultrasound Findings

F Toscano, Roberta Gallo, Giuseppe Laurelli, Raffaella Del Papato, Lucio Cipullo
article en

Abstract

An angular pregnancy is a rare form of ectopic implantation. We report a 30-year-old primigravida presenting with an abnormal beta-human chorionic gonadotropin (b-hCG) trend. At presentation, her b-hCG was 1,950 mIU/mL. Ultrasound showed an angular gestational sac with increased vascularization and deep myometrial extension. Methotrexate was administered, achieving biochemical response but with persistent suspicious ultrasound findings, suggesting ongoing trophoblastic activity. Due to this discordance, hysteroscopic management was performed. The gestational tissue was exposed and removed using a bipolar mini-resectoscope under direct visualization. The patient was discharged the same day. Hysteroscopy may represent a safe and effective option in selected cases with discordant biochemical and imaging findings.

Cureus
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Ectopic Pregnancy Diagnosis and Management
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When Methotrexate Is Not Enough: Hysteroscopic Management of an Angular Pregnancy With Discordant Beta-Human Chorionic Gonadotropin (b-hCG) and Ultrasound Findings — F Toscano, Roberta Gallo, et al. · Cureus (2026) | TGRS Research Map | TGRS