Plasma membrane transporters Alp1 and Nrt1 mediate the uptake of benzamidine conjugates in fungi
Efflux pumps confer antifungal resistance. Benzamidine (BM) conjugates overcome resistance by enhancing intracellular accumulation, but their cellular uptake mechanism remains unclear. A screen of membrane transport protein mutants revealed that plasma membrane transporters Alp1 and Nrt1 are importers of BM conjugates and are essential for their antifungal activity.
Authors
- Ming Yuan (ORCID: https://orcid.org/0000-0002-4313-141X)
- Xueyang Jin
- Guoyun Wang
- Wenqiang Chang
- Shaohua Zhao
- Yunfan Yang
- Xue Wang (ORCID: https://orcid.org/0000-0003-0744-9882)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- The Cell Surface
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1016/j.tcsw.2026.100174
- Primary Topic
- Fungal and yeast genetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province