Dietary sugar intake as a risk factor for early-onset colorectal cancer in young New Zealanders

New Zealand's rising rates of early-onset colorectal cancer (EOCRC), particularly among Māori, underscore the growing concern about the role of metabolic dysregulation in disease development. There is increasing evidence suggesting that metabolic dysregulation associated with excessive dietary sugar intake may play a central role in colorectal carcinogenesis. Childhood obesity, impaired glucose metabolism and high consumption of sugar-sweetened beverages (SSBs) are prevalent among New Zealand youth, suggesting early metabolic dysfunction may precede and contribute to EOCRC risk. Given this, routinely measured metabolic biomarkers, including glucose and glycated haemoglobin (HbA1c), may offer early risk stratification within primary care settings. This viewpoint also considers whether reductions in SSB consumption could represent a simple and potentially impactful strategy to reduce long-term metabolic disease burden and, consequently, the incidence of EOCRC.

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Publication Details

Journal
New Zealand Medical Journal
Published
2026-04-14
DOI
https://doi.org/10.26635/6965.7378
Primary Topic
Colorectal Cancer Screening and Detection
Type
article
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article

Dietary sugar intake as a risk factor for early-onset colorectal cancer in young New Zealanders

Oliver Waddell, Krista Dawson, Frank Frizelle, Jacqueline Keenan
New Zealand Medical Journal
Colorectal Cancer Screening and Detection
article

Dietary sugar intake as a risk factor for early-onset colorectal cancer in young New Zealanders

Oliver Waddell, Krista Dawson, Frank Frizelle, Jacqueline Keenan
article en

Abstract

New Zealand's rising rates of early-onset colorectal cancer (EOCRC), particularly among Māori, underscore the growing concern about the role of metabolic dysregulation in disease development. There is increasing evidence suggesting that metabolic dysregulation associated with excessive dietary sugar intake may play a central role in colorectal carcinogenesis. Childhood obesity, impaired glucose metabolism and high consumption of sugar-sweetened beverages (SSBs) are prevalent among New Zealand youth, suggesting early metabolic dysfunction may precede and contribute to EOCRC risk. Given this, routinely measured metabolic biomarkers, including glucose and glycated haemoglobin (HbA1c), may offer early risk stratification within primary care settings. This viewpoint also considers whether reductions in SSB consumption could represent a simple and potentially impactful strategy to reduce long-term metabolic disease burden and, consequently, the incidence of EOCRC.

New Zealand Medical JournalVol. 139(1633)
University of Canterbury (NZ), University of Otago (NZ)
Zero hunger
Openalex Percentile: Top 9%
Colorectal Cancer Screening and Detection
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