Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming
), strengthening mitochondrial integrity and homeostasis for better therapeutic outcomes. In vivo evaluations reveal significant anti-aging effects, with the nanozymes notably reducing neurodegeneration and improving neuronal survival. This work highlights PdP NPs as a multifunctional nanotherapeutic platform capable of rewiring mitochondrial metabolism and homeostasis, offering a promising strategy for aging-related disease management.
Authors
- Yuanyu Huang
- Wenshu Cong
- Zinan Li
- Junyu Ning
- Yingqiu Xie (ORCID: https://orcid.org/0000-0001-8041-2192)
- Shan Gao (ORCID: https://orcid.org/0000-0001-6370-4994)
- Haiming Jing
- Wenjing Zhang
- Nan Zhang
Institutions
- Beijing Institute of Technology (CN)
- Capital Medical University (CN)
- Zhuhai People's Hospital (CN)
- Beijing Center for Disease Prevention and Control (CN)
- Zhuhai Institute of Advanced Technology (CN)
- Nazarbayev University (KZ)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1002/advs.202523931
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundamental Research Funds for the Central Universities