Non-invasive Neuromodulation Targeting Approach by Mapping Stimulations and Lesions That Modify Visual Memory
=113). We identified a network preferentially connected to lesions and stimulation sites specifically associated with changes in visual memory. Of note, the direction of this effect was inverted depending on whether lesions or stimulation occurred at younger age or an older age, consistent with prior results. This age effect was replicated in an independent dataset of patients with preclinical Alzheimer's disease (N=1240). To examine neuromodulation targets, we computed electrical field models for potential TMS sites that overlap with the networks derived from each stimulation or lesion dataset; the resulting targets intersected with established targets that demonstrated efficacy for treating memory impairment - precuneus, cortical-hippocampal network, and dorsolateral prefrontal cortex - with peak intersection at medial posterior parietal lobe, angular gyrus, and left anterior middle frontal gyrus, respectively. Future head-to-head clinical trials are needed to systematically compare these proposed neuromodulation targets against each other.
Authors
- Arielle Tambini (ORCID: https://orcid.org/0000-0001-9200-9165)
- Shan H. Siddiqi (ORCID: https://orcid.org/0000-0002-0967-9289)
- Joel L. Voss (ORCID: https://orcid.org/0000-0003-4180-9335)
- Melissa Hebscher (ORCID: https://orcid.org/0000-0002-1863-5464)
- Jordan Grafman (ORCID: https://orcid.org/0000-0001-8645-4457)
- Michael Freedberg (ORCID: https://orcid.org/0000-0003-3738-8259)
- Joshua Hendrikse (ORCID: https://orcid.org/0000-0002-1468-7080)
- Joshua S. Siegel (ORCID: https://orcid.org/0000-0002-5752-3641)
- Molly S. Hermiller (ORCID: https://orcid.org/0000-0001-7234-4695)
- Simon Kwon
- Nicole Chiulli
- Shira Cohen-Zimerman
- Maurizio Corbetta
- Gong-Jun Ji
- Eyre Ye
- Soyoung Lee
Institutions
- Florida State University (US)
- Northwestern University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Shirley Ryan AbilityLab (US)
- Harvard University (US)
- University of Padua (IT)
- Anhui Medical University (CN)
- Beijing Normal University (CN)
- University of Chicago (US)
- Mass General Brigham (US)
- Monash University (AU)
- New York University (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-14
- DOI
- https://doi.org/10.64898/2026.04.10.717784
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs