In-situ polymerization-mediated glycan density measurement on extracellular vesicle surface for acute myeloid leukemia diagnosis
EV glycan density achieved superior diagnostic accuracy (AUC = 0.904) in distinguishing acute myeloid leukemia from benign hematological diseases, outperforming direct glycan quantification. By integrating surface biophysical normalization, this platform enhances EV biomarker consistency, providing a rapid, blood-based diagnostic tool with clinical translatability for acute myeloid leukemia.
Authors
- Xiaoxia Hu (ORCID: https://orcid.org/0000-0002-2719-3805)
- Haitao Zhao (ORCID: https://orcid.org/0000-0003-4462-0394)
- Xingjie Wu (ORCID: https://orcid.org/0000-0002-8768-5633)
- Litao Zhang (ORCID: https://orcid.org/0000-0001-9004-8961)
- Xiangchun Shen
- Weifeng Long
- Ling Tao
- Cong Luo
- Jie Xiong
Institutions
- Shenyang Pharmaceutical University (CN)
- Guiyang Medical University (CN)
- Northwestern Polytechnical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1186/s12951-026-04400-7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China