Lagarocladone A, a Polycyclic Polyprenylated Acylphloroglucinol Featuring an Unprecedented Skeleton from <i>Hypericum lagarocladum</i>
exhibited hepatoprotective activity against APAP-induced cytotoxicity in HepG2 cells, potentially through attenuating oxidative stress and preserving membrane integrity.
Authors
- Lantao Lai
- Xing-Yao Li
- Haoting Du (ORCID: https://orcid.org/0000-0002-4816-0551)
- Changwei Zheng
- Ji-Ci Zhao
- Qian-Cheng Liu
Institutions
- Shenyang Pharmaceutical University (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1021/acs.joc.6c00540
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Foundation of Liaoning Province Education Administration