Stress and synaptic density in psychosis and clinical high risk: evidence from [18F]SynVesT-1 PET
= 5.19, p = 0.02) only. These findings indicate that the relationship between stress and synaptic density differs between clinical and healthy groups. The changes in the relationship between stress and synaptic density in FEP may reflect impaired adaptive neuroplasticity, providing a potential mechanism by which stress contributes to psychosis vulnerability.
Authors
- Chris Hsiao (ORCID: https://orcid.org/0009-0009-2062-3516)
- Romina Mizrahi (ORCID: https://orcid.org/0000-0001-6667-7928)
- Daniel Chartrand (ORCID: https://orcid.org/0000-0003-3397-578X)
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Pablo Rusjan (ORCID: https://orcid.org/0000-0003-0075-2918)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- M. Belen Blasco (ORCID: https://orcid.org/0009-0000-2456-9101)
- Christian Ramos-Jiménez (ORCID: https://orcid.org/0000-0003-1637-6179)
- Kankana Nisha Aji
- Johan Cohen
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Douglas College (CA)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Translational Psychiatry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1038/s41398-026-03993-9
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds de Recherche du Québec-Société et Culture
- Canadian Institutes of Health Research
- CIHR Skin Research Training Centre