Predictive Value of the COPD Assessment Test Combined with Five-Repetition Sit-to-Stand Test for Impaired Exercise Tolerance in Primary Care COPD Patients: A Comparative Study with Cardiopulmonary Exercise Testing

Purpose: This study aimed to determine the longitudinal trends of impaired exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) and to evaluate the predictive value, agreement, and longitudinal stability of the COPD Assessment Test (CAT) combined with the the Five-Repetition Sit-to-Stand Test (5STS) in relation to cardiopulmonary exercise testing. Patients and Methods: ) < 85%, as measured by CPET. Patients were evaluated for Physical Fitness at baseline and 12 months using the following tools: modified Medical Research Council (mMRC) questionnaire, CAT score, 5STS, Hand Grip Strength (HGS), Timed Up and Go (TUG) test, and Quadriceps maximal voluntary contraction (QMVC). Results: demonstrated that the CAT score and 5STS showed fair agreement, with consistently moderate predictive value across all time points. Conclusion: The combined application of the CAT score and the 5STS provides both screening and longitudinal monitoring capabilities, indicating potential for identifying patients with COPD at high risk of impaired exercise tolerance in primary care.