Contribution of Magnetic Resonance Imaging (MRI) to the Diagnosis of Progressive Supranuclear Palsy: A Case Report

Parkinson-plus syndromes are neurodegenerative disorders resembling Parkinson’s disease with additional features and faster progression, among which progressive supranuclear palsy (PSP) is a major subtype. We report a 65-year-old man with progressive gait disturbance, recurrent falls, and cognitive impairment, whose examination revealed axial rigidity and vertical gaze palsy. Brain MRI showed characteristic midbrain atrophy with “Hummingbird”, “Mickey Mouse” and “Morning Glory” signs, supporting a diagnosis of probable PSP. Despite symptomatic treatment, the patient showed no improvement and died following a fall-related intracranial hemorrhage. Diagnosis of PSP remains primarily clinical, with MRI providing supportive but not definitive diagnostic value.