Photoactivated Ruthenium-Manganese Dinuclear Complex for Tracking and Two-Pronged Antibacterial Therapy Combining CO Delivery and Photodynamic Treatment

produced by the Ru(II)-complex moiety while restoring intrinsic MLCT luminescence, which facilitates real-time tracking of the generation process through the turn-on luminescence of the Ru(II)-complex. In vitro experiments demonstrate that the synergistic antibacterial effect significantly enhances efficacy compared to monofunctional systems, achieving complete eradication of both Gram-negative and Gram-positive bacteria at concentrations as low as 1 μM under 10 min of light exposure and effectively disrupting drug-resistant bacterial biofilms. Furthermore, in vivo studies in a murine-infected wound model confirm its potent therapeutic efficacy. This work successfully developed a multifunctional molecular tool based on transition metal complexes with both antibacterial and tissue-regenerative capabilities, offering an insight for development of antibacterial reagents and bacterial infection treatment.