Protective Efficacy of Selenium in Cisplatin-Induced Retinal Toxicity: An Experimental Immunohistochemical and Ultrastructural Analysis

: Systemic cisplatin induces severe subcellular retinal toxicity characterized by mitochondrial damage and photoreceptor degeneration. Selenium supplementation attenuates these effects; however, outcome patterns differ by administration route. Intraperitoneal selenium was associated with greater morphological and ultrastructural preservation despite persistent IL-6 elevation, whereas oral selenium normalized immunohistochemical marker expression to near-control levels but was associated with more pronounced residual subcellular damage on qualitative TEM assessment. These preliminary morphological and immunohistochemical findings suggest that the route of selenium delivery may influence its neuroprotective profile; however, pharmacokinetic measurements and functional retinal assessments, such as electroretinography, are warranted before its clinical translation.

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Journal
Nutrients
Published
2026-04-14
DOI
https://doi.org/10.3390/nu18081236
Primary Topic
Chemotherapy-induced organ toxicity mitigation
Type
article
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article

Protective Efficacy of Selenium in Cisplatin-Induced Retinal Toxicity: An Experimental Immunohistochemical and Ultrastructural Analysis

Dimitrios Kouvelas, Georgios Delis, Theodora Papamitsou, Sofia Karachrysafi et al.
Nutrients
Chemotherapy-induced organ toxicity mitigation
article

Protective Efficacy of Selenium in Cisplatin-Induced Retinal Toxicity: An Experimental Immunohistochemical and Ultrastructural Analysis

Dimitrios Kouvelas, Georgios Delis, Theodora Papamitsou, Sofia Karachrysafi, Vasilis‐Spyridon Tseriotis, Ioannis K. Konstantinidis, Chrysanthi Sardeli, Dimitrios Kavvadas, Sophia Tsokkou, Kyriaki Papadopoulou, Antonia Siogka, Pavlos Pavlidis
article en

Abstract

: Systemic cisplatin induces severe subcellular retinal toxicity characterized by mitochondrial damage and photoreceptor degeneration. Selenium supplementation attenuates these effects; however, outcome patterns differ by administration route. Intraperitoneal selenium was associated with greater morphological and ultrastructural preservation despite persistent IL-6 elevation, whereas oral selenium normalized immunohistochemical marker expression to near-control levels but was associated with more pronounced residual subcellular damage on qualitative TEM assessment. These preliminary morphological and immunohistochemical findings suggest that the route of selenium delivery may influence its neuroprotective profile; however, pharmacokinetic measurements and functional retinal assessments, such as electroretinography, are warranted before its clinical translation.

NutrientsVol. 18(8)
Johannes Gutenberg University Mainz (DE), Aristotle University of Thessaloniki (GR), Agios Pavlos General Hospital (GR), University Medical Center of the Johannes Gutenberg University Mainz (DE)
Openalex Percentile: Top 26%
Chemotherapy-induced organ toxicity mitigation
DOIOpen Access PDFOpenAlex
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Protective Efficacy of Selenium in Cisplatin-Induced Retinal Toxicity: An Experimental Immunohistochemical and Ultrastructural Analysis — Dimitrios Kouvelas, Georgios Delis, et al. · Nutrients (2026) | TGRS Research Map | TGRS