Mechanism of Cancer‐Associated Fibroblasts‐Derived NEAT1 Promoting Pancreatic Cancer Cell Stemness via the miR‐101‐3p/KDM3A Axis

cell count. CAFs-EVs-delivered NEAT1 potentiated PANC-1 cell stemness by downregulating miR-101-3p. NEAT1 upregulated KDM3A expression by inhibiting miR-101-3p. KDM3A knockdown partly reversed CAFs-EVs-carried NEAT1-promoted PANC-1 cell stemness. CAFs-EVs-shuttled NEAT1 encouraged PANC-1 cell stemness via the miR-101-3p/KDM3A axis. CAFs-EVs might carry lncRNA NEAT1 to inhibit miR-101-3p expression, thereby regulating KDM3A and eventually facilitating PC cell stemness.

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Publication Details

Journal
Journal of Biochemical and Molecular Toxicology
Published
2026-04-01
DOI
https://doi.org/10.1002/jbt.70817
Primary Topic
Extracellular vesicles in disease
Type
article
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article

Mechanism of Cancer‐Associated Fibroblasts‐Derived NEAT1 Promoting Pancreatic Cancer Cell Stemness via the miR‐101‐3p/KDM3A Axis

J Li, Yang Zhou
Journal of Biochemical and Molecular Toxicology
Extracellular vesicles in disease
article

Mechanism of Cancer‐Associated Fibroblasts‐Derived NEAT1 Promoting Pancreatic Cancer Cell Stemness via the miR‐101‐3p/KDM3A Axis

J Li, Yang Zhou
article en

Abstract

cell count. CAFs-EVs-delivered NEAT1 potentiated PANC-1 cell stemness by downregulating miR-101-3p. NEAT1 upregulated KDM3A expression by inhibiting miR-101-3p. KDM3A knockdown partly reversed CAFs-EVs-carried NEAT1-promoted PANC-1 cell stemness. CAFs-EVs-shuttled NEAT1 encouraged PANC-1 cell stemness via the miR-101-3p/KDM3A axis. CAFs-EVs might carry lncRNA NEAT1 to inhibit miR-101-3p expression, thereby regulating KDM3A and eventually facilitating PC cell stemness.

Journal of Biochemical and Molecular ToxicologyVol. 40(4)
Central South University (CN), Xiangya Hospital Central South University (CN)
Good health and well-being
Openalex Percentile: Top 17%
Extracellular vesicles in disease
DOISourceOpenAlex
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Mechanism of Cancer‐Associated Fibroblasts‐Derived NEAT1 Promoting Pancreatic Cancer Cell Stemness via the miR‐101‐3p/KDM3A Axis — J Li, Yang Zhou · Journal of Biochemical and Molecular Toxicology (2026) | TGRS Research Map | TGRS