Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation
species. Our work uncovers a dual regulatory paradigm: Epigenetic constraints harmonize neuron-type robustness and plasticity, while enhancer co-option enables evolutionary innovation. This mechanistic plasticity directly links regulatory adaptation to behavioral diversification.
Authors
- Rafael Alis (ORCID: https://orcid.org/0000-0002-9169-5084)
- Carla Lloret-Fernández (ORCID: https://orcid.org/0000-0002-5370-9318)
- Carlos Mora‐Martínez (ORCID: https://orcid.org/0000-0002-0542-2654)
- Andrea Millán-Trejo (ORCID: https://orcid.org/0000-0003-0003-0173)
- Nuria Flames (ORCID: https://orcid.org/0000-0003-0961-0609)
- Arantza Barrios (ORCID: https://orcid.org/0000-0001-6153-8830)
- Antonio Jordán‐Pla (ORCID: https://orcid.org/0000-0001-7343-4633)
- Adrián Tarazona-Sánchez
Institutions
- Instituto de Biomedicina de Valencia (ES)
- University College London (GB)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1073/pnas.2524709123
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Generalitat Valenciana
- National Institutes of Health
- HORIZON EUROPE European Research Council