Apoptotic-mimetic nanovesicles orchestrate immune–vascular–osteogenic crosstalk for critical-sized craniofacial bone regeneration
, thereby coupling angiogenesis with osteogenesis, while simultaneously inhibiting the NF-κB pathway to inhibit inflammation. This study pioneers a versatile apoptotic vesicle-based platform that harmonizes the immune-osteogenic-vascular triad, presenting a potent and promising therapeutic paradigm for regenerative medicine.
Authors
- Siman Huang
- Haoze Zhu
- Likai Chen
- Zuchang Liu
- Cailong Liu
- Yueyue Huang
- Yiyu Li (ORCID: https://orcid.org/0009-0005-5761-3216)
- Xiaokun Li
- Min Zhang
- Hao Pan
Institutions
- Tongji University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103119
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China