Cryoballoon-Based Left Atrial Appendage Isolation and Closure in Patients with Atrial Fibrillation—The LALALAND Pilot Study

While CB-based LAAI may offer benefits in managing persistent AF, it presents a significant risk of thrombus formation in the LAA, even with appropriate OAC. Early closure of the LAA following LAAI appears promising in mitigating these risks, but further evidence is needed to establish clear best practices.

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Publication Details

Journal
Journal of Clinical Medicine
Published
2026-04-14
DOI
https://doi.org/10.3390/jcm15082980
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Cryoballoon-Based Left Atrial Appendage Isolation and Closure in Patients with Atrial Fibrillation—The LALALAND Pilot Study

Samuel Reincke, Charlotte Eitel, Christian-Hendrik H. Heeger, S S Popescu et al.
Journal of Clinical Medicine
Atrial Fibrillation Management and Outcomes
article

Cryoballoon-Based Left Atrial Appendage Isolation and Closure in Patients with Atrial Fibrillation—The LALALAND Pilot Study

Samuel Reincke, Charlotte Eitel, Christian-Hendrik H. Heeger, S S Popescu, Sascha Hatahet, Anna Traub, Roland R. Tilz, Behnam Subin, Karl-Heinz Kuck
article en

Abstract

While CB-based LAAI may offer benefits in managing persistent AF, it presents a significant risk of thrombus formation in the LAA, even with appropriate OAC. Early closure of the LAA following LAAI appears promising in mitigating these risks, but further evidence is needed to establish clear best practices.

Journal of Clinical MedicineVol. 15(8)
Asklepios Klinik Altona (DE), Universitäres Kinderwunschzentrum Lübeck (DE), University Hospital Schleswig-Holstein (DE), German Centre for Cardiovascular Research (DE), University of Lübeck (DE)
Openalex Percentile: Top 24%
Atrial Fibrillation Management and Outcomes
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Cryoballoon-Based Left Atrial Appendage Isolation and Closure in Patients with Atrial Fibrillation—The LALALAND Pilot Study — Samuel Reincke, Charlotte Eitel, et al. · Journal of Clinical Medicine (2026) | TGRS Research Map | TGRS