Comparison of Krushna Jeerakadi Yoga (Lotion) and Mrudvikadi Lotion for Mukhapaka (stomatitis) in Children: A Randomised Interventional Study Protocol

Introduction: The oral cavity is one of the most vital components of the human body, playing a key role in digestion and communication. Stomatitis (Mukhapaka) is a common inflammatory condition of the oral mucosa frequently encountered in the paediatric population. It is characterised by symptoms such as pain, ulceration, and excessive salivation, which often interfere with daily activities such as eating and speaking. In Ayurveda, this condition is associated with the vitiation of Pitta and Kapha doshas. Need of the study: Due to contemporary dietary habits, irregular meal timings, night-time wakefulness, and improper oral hygiene practices, children are increasingly prone to inflammatory oral disorders. Although modern medicine utilises antibiotics and antiinflammatory drugs for treatment, there remains a need for an affordable, safe, and effective Ayurvedic therapeutic approach. Classical Ayurvedic texts mention Krushna Jeerakadi Yoga and Mrudvikadi Lotion as effective treatments; however, their relative efficacy has not yet been established through clinical trials. Aim: To assess the comparative effectiveness of an altered dosage form of Krushna Jeerakadi Yoga (Lotion) and Mrudvikadi Lotion in paediatric patients suffering from Mukhapaka (Stomatitis). Material and Methods: The present study will be a randomised controlled interventional clinical scheduled to be conducted from June 2025 to June 2026 involving 60 children aged 5-16 years diagnosed with Mukhapaka. Participants will be randomly divided into two groups of 30 each. Group A will receive Mrudvikadi Lotion (control group), while Group B will receive the altered dosage form of Krushna Jeerakadi Yoga Lotion (trial group) for seven days. Clinical evaluation will be conducted on the 3rd, 5th, and 7th days, with a final assessment on the 14th day. Outcomes will be measured using the World Health Organisation (WHO) Stomatitis (oral mucositis) Grading Scale along with symptom-relief parameters.