Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics
dynamics, cross-species discrepancies, and achievement of durable, context-specific modulation. The future of "macrophage medicine" hinges on integrating spatial multi-omics and advanced imaging to enable spatiotemporally precise interventions, ultimately leveraging the cell's inherent plasticity for therapeutic gain.
Authors
- J Liu
- Dongliang Yang
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Mengxiao Zhao
- Liwei Chen
- Jieliang Chen
- Kathrin Sutte
- Xin Zheng
- Mengji Lu
- Xuecheng Yang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Huashan Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-14
- DOI
- https://doi.org/10.3389/fimmu.2026.1814879
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China
- National Mega Project on Major Infectious Disease Prevention